Fig. 2
From: Finding directionality and gene-disease predictions in disease associations
Gene and disease network analysis. a Number of OMIM phenotypes and codes by ICD-10-CM category. b Number of unique disease-genes by ICD-10-CM category and the number of enzyme-producing genes. c 880 unique ICD-10-CM codes are linked to 3083 genes with phenotype-causing mutation creating 4241 disease-gene associations. Of the 880 codes a total of 705 codes and 1587 genes are linked to 801 metabolic pathways creating 15,455 code-gene-pathway interactions. A further analysis revealed a total of 6706 genes being involved in at least one KEGG metabolic pathway, and hereby 5119 genes with no known phenotype-causing mutation could be included in our analysis. These 5119 genes with no known phenotype-causing mutation are linked to 546 different KEGG pathways sharing 479 pathways with genes carrying phenotype-causing mutation and are only linked to 67 additional KEGG metabolic pathways