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Fig. 1 | BMC Systems Biology

Fig. 1

From: Complex regulation of Hsf1-Skn7 activities by the catalytic subunits of PKA in Saccharomyces cerevisiae: experimental and computational evidences

Fig. 1

Scheme for the development of a dynamic computational model for the simulation of the regulation of HSE-dependent gene expression by the PKA-RN. A PKA-RN composed of 15 elements was simulated in a dynamic computational model (see Additional file 3: Supplementary Information). In this scheme Cdc25, Ras2, Cyr1, Tpk1, Tpk3, Hsf1, and Skn7 act as positive regulators. Bcy1, an unidentified repressor of Hsf1/Skn7 (Repressor X), cAMP, and heat shock act as repressors. Interestingly, in this scheme Ssa1, Ssa2, and Tpk2 interactions are complex acting both as activators and as repressors. The experimental evidence that accounts for the activities and interactions of the components is described in the Background and Results and discussion sections

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