Identification of putative drug targets for human sperm-egg interaction defect using protein network approach

BMC Systems Biology

Table 2 The high degree nodes with evaluated BC and CC in sperm-egg protein network

Gene name	Protein family	Degree	BC	CC
ITGB1	Integrins	33	0.2	0.5
FN1	Fibronectin	30	0.1	0.5
EGFR	Epidermal growth factor receptors	26	0.2	0.5
ITGA3	Integrins	25	0.03	0.5
ITGAV		24	0.03	0.5
ITGB3		23	0.02	0.5
COL1A1	Collagens	22	0.02	0.5
CD9	Tetraspanins	21	0.1	0.5
ITGB4	Integrins	20	0.04	0.5
ITGA5		19	0.04	0.5
ITGB8		18	0.01	0.4
ITGB5		17	0.01	0.4
ITGA2		17	0.01	0.4

Half of the maximum degree and BC of the network were used as the critical point of high degree and high BC nodes and in order to check topological centrality of hubs and bottlenecks in the network, CC values of the protein set were measured. The proteins from integrin, fibronectin, epidermal growth factor receptor, collagens and tetraspanin protein families are hub nodes that have a large BC
BC betweennes centrality, CC closeness centrality

ISSN: 1752-0509