Table 1 Parameter ranges used in the trend shape simulation of reference data (via Eqs. 1-3). Parameter values were drawn from a uniform distribution constrained to the given ranges. Where two ranges are given, the range was chosen randomly for each trend based on the given probability
| Trend | Parameter | Range 1 | Range 2 | P(Range 1) |
|---|---|---|---|---|
| Sigmoidal decrease | a | 0.200–0.600 | 0.600–0.900 | 0.05 |
| b | 0.100–0.180 | NA | 1.00 | |
| Sigmoidal increase | a | 0.045–0.055 | 0.945–0.955 | 0.15 |
| b | 0.200–0.400 | 0.100–0.300 | 0.15 | |
| Concave | a | 3.500–4.500 | NA | 1.00 |
| b | 2.500–3.500 | NA | 1.00 | |
| c | 0.000–0.200 | NA | 1.00 | |
| d | 0.800–0.900 | NA | 1.00 |