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Table 1 List of metabolic engineering targets

From: Flux-sum analysis identifies metabolite targets for strain improvement

Objective Target metabolites Flux-sum perturbation Experimental validation
Enhance ethanol production Acetate Attenuation [25, 26]
  Acetylphosphate Attenuation [25, 26]
  Formate Attenuation N.A.
  6-Phospho-D-gluconate Intensification N.A.
  Erythrose 4-phosphate Intensification N.A.
  5,10-Methylenetetrahydrofolate Intensification N.A.
  Sedoheptulose 7-phosphate Intensification N.A.
Enhance succinate production Pyruvate Attenuation [11]
  Glyoxylate Intensification [30, 31]
  Menaquinone/menaquinol Intensification N.A.
Minimize acetate production Acetate Attenuation [34, 35]
  Acetylphosphate Attenuation [34, 35]
  3-Phosphoglycerate Intensification N.A.
  4-Methyl-2-oxopentanoate Intensification N.A.
  Isocitrate Intensification [36]
  Lactate Intensification [34]
  Ribulose 5-phosphate Intensification N.A.
  Succinic semialdehyde Intensification N.A.