Fig. 1

The Drosophila sex determination hierarchy in females. Transcripts are in red and proteins are in blue. Solid arrows are genetic interactions (e.g. splicing, transcription) and dashed arrows are protein translation. (1) Spf45 → Sxl [122], (2) Snf → Sxl [123], (3) vir → Sxl [27], (4) vir → tra [27], (5) fl(2)d → Sxl [10], (6) Sxl → Sxl [122], (7) Sxl → Tra [28, 124], (8) Sxl -| Msl-2 [2, 88, 125], (9) fl(2)d → Tra [126], (10) Tra → DsxF [71], (11) Tra2 → DsxF [71], (12) DsxF → Yps [16, 127, 128], (13) Her → Yps [129], (14) ix → Yps [67]