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Fig. 2 | BMC Systems Biology

Fig. 2

From: The wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in drosophila melanogaster

Fig. 2

Identification of appropriate covariance structure for baseline model. Three separate covariance models were compared for the DSPR (a-c) and the CEGS (d-e). The full covariance model (a and d) allows all independent, or exogenous, genes to freely co-vary (blue lines). The full covariance model implies that there are unknown regulatory factor(s) that is drive expression of the genes in the sex hierarchy GRN. The no covariance model (b and e) constrains all covariances between exogenous genes to 0. The no covariance implies that the independent genes in the model are truly independent and are not regulated by some unknown factor. The partial covariance model (c and f) allows exogenous genes to freely covary (blue lines). The partial covariance models implies that some of the exogenous genes in the sex hierarchy GRN may be controlled by an unknown factor such as the transcriptional or splicing machinery

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