Fig. 3

New paths added in both the DSPR and CEGS populations. Directional arrows represent the path between genes. The baseline sex hierarchy SEM is indicated with black arrows and is based on the current understanding of the literature (summarized in Fig. 1). Twelve additional paths improved model fit for both the DSPR and CEGS population compared to their respective baseline models (Fig. 2). Ten of these show bi-directional relationships (blue arrows) and two had a single directional relationship (unidirectional red arrows)