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Fig. 7 | BMC Systems Biology

Fig. 7

From: Nonlinear mixed-effects modelling for single cell estimation: when, why, and how to use it

Fig. 7

Parameter estimation for Model 2. Analysis in the case of simulated data and parameter estimation for the parameter td in the case of known noise for Model 2 using data that is: a under good condition, b sparse sampling, c noisy, and d with a weak input signal respectively. The results are normalized by dividing with the known true value. The x-axes corresponds to the 200 simulated datasets. In comparison, the results from the parameter estimation are similar between STS and Monolix in the case of the Original Data, but there is a clear advantage of using Monolix when the quality of the data decreases

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