Fig. 2
From: Metabolic modeling predicts metabolite changes in Mycobacterium tuberculosis
Predicted changes in lipid production are deletion or induction of phoP and dosR. a Predicted changes in lipid production in a phoP knockout strain. E-Flux-MFC correctly predicts the change in production of 7/7 previously-measured changes in lipid production in phoP knockout mutants [25, 86, 87]. b Predicted changes in lipid production in a dosR knockout strain after the induction of hypoxia (2Â h 0.2Â % O2) [23]. TAG production significantly increased, in agreement with expectations based on previous observations. c Predicted changes in lipid production after the induction of phoP. d Predicted changes in lipid production after the induction of dosR. e Predictions of changes in lipid production specific to the direct regulon of phoP after induction. Direct regulon from ChIP-Seq data [31]. f Predicted changes in lipid production specific to the direct regulon of DosR after induction. Abbreviations: TAG triacylglycerols, PDIM phthiocerol dimycocerosates, SL-1 sulfolipids, PAT polyacyltrehalose, DAT diacyltrehalose, TDM trehalose dimycolates, TMM trehalose monomycolates