Fig. 4

Consequences of gene dosage. 1) WT cell: a correct number of gene copies and expression gives a correct production of C. Amplification/Over expression of B can increase the output. Under expression of B can diminish the production of C. 2) WT cell: a correct number of gene copies and expression form a correct complex DE producing F. Amplification/Over-expression of D can interfere with stoichiometry of protein complex inhibiting F. Deletions/Under-expression of D not form complex DE and not produce F