Integrating genetics and epigenetics in breast cancer: biological insights, experimental, computational methods and therapeutic potential

Table 1 Genes mutated and their alterations in BC

Genes	Genetic alterations	References
MYC	Amplifications and translocations	[25–29]
CCND1	Amplifications and Translocations	[30]
HER2	Amplifications	[15–18]
TOP2A	Amplifications or Deletions	[22, 23]
PIK3CA, MET	Amplifications	[24]
PNRC1	Deletions	[15]
DBC1 and DEC1	Amplifications or Deletions	[15]
TSPAN1	Deletions	[33]
EGFR	Amplifications	[19, 20]
ESR1	Amplifications	[32]
EMSY	Amplifications	[34]

ISSN: 1752-0509