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Table 2 Genes differentially methylated in BC

From: Integrating genetics and epigenetics in breast cancer: biological insights, experimental, computational methods and therapeutic potential

Genes

Biological effects

References

RASSF1A and CCND2

Significantly more methylated in the ER+ than ER− cancers

[69]

PGR, TFF1, CDH13, TIMP3, HSD17B4, ESR1 and BCL2

The inverse correlations were found between their hypermethylation and ER expression

[70]

ESR1, TGFBR2, PTGS2 and CDH13

They were associated with PR expression

[70]

FAM124B, ST6GALNAC1, NAV1 and PER1

The methylation status were quite different between ER+/PR+ and ER−/PR− BC

[71]

RASSF1A, CCND2, TWIST, HIN1

Low levels of methylation were detected in normal control samples

[74]

CCND2, RASSF1A, APC and HIN1

Able to distinguish between invasive carcinomas, fibroadenomas, and normal tissue

[66]

ITIH5, DKK3, and RASSF1A

Early detection of BC

[74]

APC, BIN1, BMP6, BRCA1, CST6, ESR-b, GSTP1, P16, P21 and TIMP3

Able to distinguish between cancerous and normal tissues

[67]

CST6

Differentially methylated between BC and control plasma samples

[75]