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Table 1 Kinetic isotope effects measured on five central metabolic enzymes. For multiply labeled isotopomers, α coefficients were approximated from KIEs of singly labeled isotopomers assuming KIEs are cumulative [28]; for instance, α PYR_110 PDH  = α PYR_100 PDH . α PYR_010 PDH

From: Impact of kinetic isotope effects in isotopic studies of metabolic systems

Enzyme Reaction Substrate Isotopomer α Ref.
6-phosphogluconate dehydrogenase GND PGN 100000 0.9905 [48]
glucose-6-phosphate dehydrogenase G6PDH G6P 100000 0.9837 [49]
fructose-1,6-bisphosphate aldolase ALD FBP 001000 0.9843 [50]
ribulose-5-phosphate epimerase RPE RB5P 01000 0.9931 [51]
00100 0.9818
00010 0.9852
00001 0.9980
pyruvate dehydrogenase PDH PYR 100 0.9908 [52]
010 0.9791
001 0.9969