Fig. 1

Identifiability issue in two parameter case. When data points are not well-distributed, parameter identification can be difficult. This shows the curve for parameters predicted from two possible data sets, one with points gathered in the saturation region (where reaction rates asymptotically approach a maximum level) in (a) and in the other in the linear region (where substrate concentrations are small and reaction rates increase almost linearly with substrate concentrations) in (b)