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Fig. 1 | BMC Systems Biology

Fig. 1

From: Mathematical analysis of the regulation of competing methyltransferases

Fig. 1

Folate and methionine metabolism with competing methyltransferases. Substrates are indicated by rectangular boxes, green in the methionine cycle and red in the folate cycle, except for GNMT which is both an enzyme and a substrate since it can bind to two molecules of 5mTHF. Each arrow represents a biochemical reaction and the blue ellipse on the arrow contains the acronym of the enzyme that catalyzes the reaction. Substrate abbreviations: Met, methionine; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; Hcy, homocysteine; 5mTHF, 5-methyltetrahydrofolate; THF, tetrahydrofolate; 10fTHF, 10-formyltetrahydrofolate; DHF, dihydrofolate; CH2-THF, 5,10-methylenetrahydrofolate; CH=THF, 5,10-methenyltetrahydrofolate. Enzyme abbreviations: AICAR(T), aminoimidazolecarboxamide ribonucleotide (transferase); FTD, 10-formyltetrahydrofolate dehydrogenase; FTS, 10-formyltetrahydrofolate synthase; MTCH, 5,10-methylenetetrahydrofolate cyclohydrolase; MTD, 5,10-methylenetetrahydrofolate dehydrogenase; MTHFR, 5,10-methylenetetrahydrofolate reductase; TS, thymidylate synthase; SHMT, serine hydroxymethyltransferase; PGT, phosphoribosyl glycinamidetransformalase; DHFR, dihydrofolate reductase; NE, nonenzymatic interconversion of THF and 5,10-CH2-THF; MAT-I,methionine adenosyl transferase I; MAT-III, methionine adenosyl transferase III; GNMT, glycine N-methyltransferase; AS3MT, arsenic methyltransferase; PEMT, phosphotidylethanolamine methyltransferase; GAMT, gunadino-acetate methyltransferase; DNMT, DNA-methyltransferase; SAHH, S-adenosylhomocysteine hydrolase; CBS, cystathionine β-synthase; MS, methionine synthase; BHMT, betaine-homocysteine methyltransferase

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