Fig. 3
From: Mathematical analysis of the regulation of competing methyltransferases
Steady state changes in methylation velocities when one velocity is knocked out or upregulated. Panel a shows the percentage changes in methylation velocities in the model when either PEMT, GAMT, or GNMT is knocked out, or when DNMT is 20-fold upregulated. Because of the long-range interactions, GNMT flux changes a lot so that the change is SAM is modest and the PEMT and GAMT fluxes do not change so much. Panel b shows the results of the same experiments in the case that the long-range interactions are turned off. All the changes are greater than those in Panel a