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Fig. 2 | BMC Systems Biology

Fig. 2

From: Optimization of lipid production with a genome-scale model of Yarrowia lipolytica

Fig. 2

Lipid accumulation and citrate excretion in nitrogen-limited fermentations. In batch fermentations where nitrogen is completely consumed before glucose depletion, growth of Y. lipolytica is arrested but the cells continue to take up glucose. In the following lipid production phase, the glucose is converted to citrate, which is used for acetyl-CoA and subsequent fatty acid synthesis or excreted (a). If iMK735 is constrained according to the measured glucose uptake and citrate excretion rate, the lipid synthesis rate can be predicted with high accuracy (b)

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