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Fig. 8 | BMC Systems Biology

Fig. 8

From: Robust and efficient parameter estimation in dynamic models of biological systems

Fig. 8

Calibration and cross-validation results for the BBG case study. Left figure shows calibration data fitted with non-regularized and regularized estimations (non-regularized, \(Q_{\text {LS}}(\hat \theta) = 3.68\) and regularized \(Q_{\text {LS}}(\hat \theta _{\alpha }) = 4.09\)). Right figure shows cross-validation data with the predictions from the non-regularized and regularized estimations. The regularized model shows a slightly worse fit to the calibration data but much better agreement with the cross-validation data. I.e. regularization results in a more generalizable model

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