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Fig. 10 | BMC Systems Biology

Fig. 10

From: Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes

Fig. 10

Alternate parameter changes that can reproduce experimental liver regeneration profiles in humans. Parameters were varied to fit experimental data of human mass recovery to test several possible hypotheses about how human liver regeneration differs from rat: the hypothesis that humans have a higher stress response than rats (blue, MSE = 6.1x10-3), the hypothesis that humans store a greater quantity of growth factors in the ECM that is liberated early post-PHx and may have an altered ECM production/degradation balance (red, MSE = 6.25x10-3), the hypothesis that human hepatocytes have a higher transition time between physiological states (green, MSE = 0.25x10-3), the hypothesis that humans have a longer cell cycle, a higher apoptosis rate, a higher requiescence rate, and a higher transition rate between physiological states as was assumed by Periwal et al. [29] (magenta, MSE = 12.16x10-3), and the hypothesis that only the metabolic demand parameter changes (black, MSE = 4.91x10-3). a Simulated mass recovery compared to experimental data [28]. b Mass recovery over the first 30 days following resection. c Fraction of replicating cells (simulated BrdU incorporation) post-resection. d IL-6 levels post-resection. e GF levels post-resection. f ECM accumulation post-resection. It may be possible to differentiate between most of these hypotheses by measuring at 30 days post-resection (g) IL-6, (h) GF, and (i) ECM. To differentiate between the high transition time hypotheses (green) and the hypothesis presented by Periwal et al. (orange), it may also be necessary to measure mass recovery. Approximately two weeks post-resection showed the maximum difference between mass recovery between these two hypotheses. MSE = Mean Squared Error between experimental and simulated data

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