Table 3 Patterns of molecular regulation (30Â days) and mass recovery (14Â days) that could differentiate hypotheses of mechanisms underlying liver regeneration in humans
Hypothesis | IL-6 / Inflammation | GF | ECM | Mass Recovery |
|---|---|---|---|---|
(1) Altered Inflammation | Moderate | High | High | High |
(2) Altered ECM remodeling and GF storage | High | Moderate | High | Moderate |
(3) Altered transition times | High | High | Moderate | High |
(4) Parameter changes assumed in Periwal et al. [29] | High | High | Moderate | Low |
(5) Lower metabolic demand | Moderate | Moderate | High | Moderate |