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Fig. 2 | BMC Systems Biology

Fig. 2

From: In silico evaluation and exploration of antibiotic tuberculosis treatment regimens

Fig. 2

Average bacterial and antibiotic dynamics in simulated granulomas for the first 7 days of treatment with INH (a-c), RIF (d-f) or INH + RIF (g-i) for 7, 3 and 2 doses per week regimens. INH (a-c) and RIF (d-f) concentrations (orange curves) inside granulomas are plotted on left vertical-axes; bacterial subpopulations (purple, blue, green and red) are plotted on right vertical-axes (all panels). Solid curves are mean and dashed curves are +/− SEM (N = 417). Black lines are C50 values (C50: concentration where antibiotic reaches 50 % of its maximal activity) for intracellular (C50,BI), extracellular (C50,BE) and non-replicating (C50, BN) bacterial populations

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