Fig. 5
From: In silico evaluation and exploration of antibiotic tuberculosis treatment regimens
Regions of granuloma predicted to harbor bacterial populations at risk of developing drug resistance during treatment with RIF, and bacterial loads in these high-risk regions. a Snapshot of in silico granuloma at 100 d.p.i, prior to treatment. b Outlines of granuloma (gray) and caseum (purple) for the granuloma in (a). c-e Regions with RIF exposure (C max /C 50 ) in the high-risk range (0.009 to 0.07) are shown in blue for intracellular, non-replicating, and replicating extracellular bacteria. Bacteria in each subpopulation are shown in yellow. f, g Number of bacteria in high-risk regions after two weeks and 6 months of treatment for all granulomas (N = 417). h, i Total number of Mtb per granuloma, separated based on sterilization. Panels in (f-i) show mean +/− SEM