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Fig. 2 | BMC Systems Biology

Fig. 2

From: Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data

Fig. 2

Estimated evidence for alternative models and comparison of model predictions with experimental data. a Estimated marginal likelihoods for 12 alternative models. b Estimated marginal likelihoods for highly ranked models (Models 4, 8, and 12) after incorporation of additional data on FOXP3 protein levels. c Experimental data on FOXP3 protein levels (the percentage of cells expressing FOXP3 protein at time 72 h) plotted with the corresponding predicted average FOXP3 levels as a function of added TGF β (predictions are generated using Models 4, 8, and 12, and the dimensionless latent FOXP3 level is multiplied by 104 for illustrative purposes). The experimental data (black squares) shown as mean ± standard deviation are representative of 3 independent experiments. The dashed and solid lines represent the predictions generate before and after incorporation of FOXP3 protein level data, respectively

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