Skip to main content
Fig. 7 | BMC Systems Biology

Fig. 7

From: A multi-omic analysis of human naïve CD4+ T cells

Fig. 7

T cell receptor signaling pathway showing downstream mediators regulated by DNA methylation, gene/protein expression and/or protein phosphorylation. T cell receptor signaling pathway depicting genes with their corresponding promoter methylation status, gene and protein expression levels and phosphorylation status between naïve and memory T cells. Promoter methylation status, transcriptomic, proteomic and phosphoproteomic measurements were imported into GeneSpring and overlaid onto the TCR signaling pathway to identify molecular signatures underlying the transition from naïve CD4+ T cells to memory CD4+ T cells. Different shapes are used to denote promoter methylation, mRNA, protein and phosphorylation status. Red indicates high in naïve CD4+ T cells, blue indicates high in memory CD4+ T cells and the unchanged are depicted in white. Different colored arrows are used to depict various modes of regulation of pathway components

Back to article page