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Table 1 Cytokine and hormone concentrations throughout lactation

From: Bayesian modeling suggests that IL-12 (p40), IL-13 and MCP-1 drive murine cytokine networks in vivo

Mediator

NC (n = 7)

Day 1 (n = 8)

Day 2 (n = 8)

Day 4 (n = 8)

Day 10 (n = 7)

Day 16 (n = 8)

Day 21 (n = 7)

Day 24 (n = 7)

IL-1α

0.52 ± 0.41a

3.40 ± 1.35ab

2.20 ± 0.75ab

7.46 ± 2.78bc

12.32 ± 2.42c

15.48 ± 2.16c

15.06 ± 2.85c

13.16 ± 1.81c

IL-1β

34.83 ± 11.89

50.12 ± 14.37

55.17 ± 6.45

57.21 ± 10.81

74.76 ± 6.21

51.07 ± 6.09

83.24 ± 25.51

41.59 ± 8.66

IL-2

5.67 ± 1.41a

12.50 ± 2.43abc

10.87 ± 1.31ab

25.25 ± 3.68d

36.73 ± 6.09e

17.75 ± 2.77bcd

25.38 ± 4.81d

18.08 ± 3.49cd

IL-3

1.50 ± 0.04a

1.90 ± 0.21ab

2.17 ± 0.51ac

2.77 ± 0.96ad

6.48 ± 3.33def

3.75 ± 0.84bdef

3.95 ± 1.13af

5.77 ± 2.36bcef

IL-4

0.10 ± 0.03

0.21 ± 0.06

0.19 ± 0.03

0.24 ± 0.12

0.58 ± 0.13

0.22 ± 0.05

0.53 ± 0.25

0.36 ± 0.15

IL-5

3.98 ± 0.69a

8.48 ± 1.50ab

10.32 ± 1.01bc

16.79 ± 2.54d

21.43 ± 2.24d

16.13 ± 2.48cd

17.84 ± 2.98d

13.79 ± 2.12cd

IL-6

17.08 ± 7.19a

119.81 ± 25.30b

151.52 ± 56.55b

164.98 ± 37.82b

265.95 ± 40.50b

151.35 ± 20.92b

201.91 ± 51.93b

154.86 ± 41.57b

IL-9

159.93 ± 24.69a

278.68 ± 28.05bc

236.61 ± 18.92acd

396.55 ± 46.52be

387.07 ± 28.31ef

394.43 ± 38.41be

296.10 ± 37.38bde

180.05 ± 20.59a

IL-10

5.69 ± 2.78a

18.95 ± 6.92abc

15.56 ± 6.16ac

27.99 ± 5.74ad

109.05 ± 29.77d

31.03 ± 4.86cd

45.68 ± 12.24cd

105.96 ± 62.76bd

IL-12 (p40)

164.44 ± 16.75ab

137.59 ± 37.23abc

114.44 ± 8.51b

247.74 ± 31.16ac

213.84 ± 20.94ac

160.99 ± 27.04abc

232.08 ± 11.32cd

259.51 ± 28.02cd

IL-12 (p70)

42.34 ± 17.66a

316.15 ± 101.70bc

249.58 ± 46.91bd

682.30 ± 173.51be

1222.66 ± 326.6ef

786.09 ± 90.51ef

699.93 ± 84.99ce

912.65 ± 283.08cdf

IL-13

117.81 ± 28.60a

324.07 ± 40.21b

261.46 ± 33.82ab

416.84 ± 67.09b

650.45 ± 108.10ab

334.77 ± 54.77ab

447.35 ± 86.24b

307.99 ± 69.89b

IL-17

42.17 ± 11.33a

155.83 ± 54.39abc

243.46 ± 27.76bd

391.00 ± 62.99de

477.14 ± 51.54e

446.35 ± 26.19e

441.08 ± 66.12ce

424.34 ± 55.23e

Eotaxin

115.26 ± 54.35

462.25 ± 158.06

388.22 ± 111.37

349.13 ± 55.09

517.32 ± 104.37

470.79 ± 42.03

446.18 ± 50.47

444.59 ± 33.41

G-CSF

1.28 ± 0.68a

25.06 ± 12.59bcd

11.39 ± 4.24ac

13.80 ± 2.29bc

40.38 ± 4.51d

20.45 ± 3.50bc

24.44 ± 5.15bcd

11.30 ± 2.23bcd

GM-CSF

6.62 ± 2.31a

22.41 ± 2.29bc

20.15 ± 1.84b

30.83 ± 5.85cd

44.02 ± 4.48e

32.71 ± 2.76cd

37.76 ± 4.15de

27.38 ± 4.46cd

IFN-γ

14.19 ± 3.16a

76.07 ± 14.31ab

51.22 ± 8.18a

150.66 ± 30.78cd

219.15 ± 44.86d

136.96 ± 14.43bc

160.27 ± 26.80cd

120.45 ± 35.03bc

KC

9.95 ± 1.75a

19.05 ± 3.24ab

10.36 ± 1.51a

22.66 ± 2.22b

26.26 ± 3.91b

22.89 ± 1.65b

28.51 ± 3.82b

20.39 ± 3.47ab

MCP-1

109.21 ± 11.86a

277.14 ± 23.85bc

202.25 ± 18.47ab

311.17 ± 36.45c

440.78 ± 49.29d

295.60 ± 33.14c

327.16 ± 38.26c

259.00 ± 40.22bc

MIP-1α

307.86 ± 44.49a

583.64 ± 48.62b

500.58 ± 38.00b

641.07 ± 66.25bc

813.92 ± 90.49c

501.03 ± 68.81b

672.14 ± 75.99bc

522.25 ± 72.06b

MIP-1β

17.64 ± 8.90a

97.42 ± 19.81bc

85.99 ± 17.25c

152.07 ± 30.82cd

248.47 ± 22.27e

165.79 ± 11.07d

175.62 ± 25.75dbe

173.97 ± 28.40dbe

RANTES

0.00 ± 0.00abc

2.21 ± 1.14ac

1.16 ± 0.96a

5.20 ± 2.82abc

4.79 ± 2.47abc

15.41 ± 3.52b

10.35 ± 2.82abc

10.73 ± 4.03bc

TNF-α

79.49 ± 41.61a

558.78 ± 154.41b

560.13 ± 188.57b

642.66 ± 169.61b

985.75 ± 148.06b

630.06 ± 43.70b

630.40 ± 125.34b

717.02 ± 173.20b

E2

230.63 ± 40.27

274.75 ± 111.88

96.75 ± 15.47

159.81 ± 28.44

150.16 ± 27.68

123.11 ± 15.37

205.83 ± 23.55

129.20 ± 26.77

P4

206.17 ± 46.07ab

106.89 ± 17.78a

241.39 ± 59.96ab

364.94 ± 58.13b

158.10 ± 52.16a

33.51 ± 5.28c

130.08 ± 47.18ac

243.94 ± 98.57ab

PRL

8.71 ± 4.72ab

78.88 ± 46.34acd

50.75 ± 19.27de

298.00 ± 79.05f

85.43 ± 17.26dfg

77.38 ± 43.77acdeg

1.14 ± 0.74b

7.00 ± 2.76bce

  1. Cytokine, E2 (pg/ml), PRL and P4 (ng/ml) concentrations throughout lactation (mean ± SEM). Groups that do not share a common superscript letter are significantly different from each other (P < 0.05); NC - naturally cycling