From: Bayesian modeling suggests that IL-12 (p40), IL-13 and MCP-1 drive murine cytokine networks in vivo
Mediator | NC (n = 7) | Day 1 (n = 8) | Day 2 (n = 8) | Day 4 (n = 8) | Day 10 (n = 7) | Day 16 (n = 8) | Day 21 (n = 7) | Day 24 (n = 7) |
---|---|---|---|---|---|---|---|---|
IL-1α | 0.52 ± 0.41a | 3.40 ± 1.35ab | 2.20 ± 0.75ab | 7.46 ± 2.78bc | 12.32 ± 2.42c | 15.48 ± 2.16c | 15.06 ± 2.85c | 13.16 ± 1.81c |
IL-1β | 34.83 ± 11.89 | 50.12 ± 14.37 | 55.17 ± 6.45 | 57.21 ± 10.81 | 74.76 ± 6.21 | 51.07 ± 6.09 | 83.24 ± 25.51 | 41.59 ± 8.66 |
IL-2 | 5.67 ± 1.41a | 12.50 ± 2.43abc | 10.87 ± 1.31ab | 25.25 ± 3.68d | 36.73 ± 6.09e | 17.75 ± 2.77bcd | 25.38 ± 4.81d | 18.08 ± 3.49cd |
IL-3 | 1.50 ± 0.04a | 1.90 ± 0.21ab | 2.17 ± 0.51ac | 2.77 ± 0.96ad | 6.48 ± 3.33def | 3.75 ± 0.84bdef | 3.95 ± 1.13af | 5.77 ± 2.36bcef |
IL-4 | 0.10 ± 0.03 | 0.21 ± 0.06 | 0.19 ± 0.03 | 0.24 ± 0.12 | 0.58 ± 0.13 | 0.22 ± 0.05 | 0.53 ± 0.25 | 0.36 ± 0.15 |
IL-5 | 3.98 ± 0.69a | 8.48 ± 1.50ab | 10.32 ± 1.01bc | 16.79 ± 2.54d | 21.43 ± 2.24d | 16.13 ± 2.48cd | 17.84 ± 2.98d | 13.79 ± 2.12cd |
IL-6 | 17.08 ± 7.19a | 119.81 ± 25.30b | 151.52 ± 56.55b | 164.98 ± 37.82b | 265.95 ± 40.50b | 151.35 ± 20.92b | 201.91 ± 51.93b | 154.86 ± 41.57b |
IL-9 | 159.93 ± 24.69a | 278.68 ± 28.05bc | 236.61 ± 18.92acd | 396.55 ± 46.52be | 387.07 ± 28.31ef | 394.43 ± 38.41be | 296.10 ± 37.38bde | 180.05 ± 20.59a |
IL-10 | 5.69 ± 2.78a | 18.95 ± 6.92abc | 15.56 ± 6.16ac | 27.99 ± 5.74ad | 109.05 ± 29.77d | 31.03 ± 4.86cd | 45.68 ± 12.24cd | 105.96 ± 62.76bd |
IL-12 (p40) | 164.44 ± 16.75ab | 137.59 ± 37.23abc | 114.44 ± 8.51b | 247.74 ± 31.16ac | 213.84 ± 20.94ac | 160.99 ± 27.04abc | 232.08 ± 11.32cd | 259.51 ± 28.02cd |
IL-12 (p70) | 42.34 ± 17.66a | 316.15 ± 101.70bc | 249.58 ± 46.91bd | 682.30 ± 173.51be | 1222.66 ± 326.6ef | 786.09 ± 90.51ef | 699.93 ± 84.99ce | 912.65 ± 283.08cdf |
IL-13 | 117.81 ± 28.60a | 324.07 ± 40.21b | 261.46 ± 33.82ab | 416.84 ± 67.09b | 650.45 ± 108.10ab | 334.77 ± 54.77ab | 447.35 ± 86.24b | 307.99 ± 69.89b |
IL-17 | 42.17 ± 11.33a | 155.83 ± 54.39abc | 243.46 ± 27.76bd | 391.00 ± 62.99de | 477.14 ± 51.54e | 446.35 ± 26.19e | 441.08 ± 66.12ce | 424.34 ± 55.23e |
Eotaxin | 115.26 ± 54.35 | 462.25 ± 158.06 | 388.22 ± 111.37 | 349.13 ± 55.09 | 517.32 ± 104.37 | 470.79 ± 42.03 | 446.18 ± 50.47 | 444.59 ± 33.41 |
G-CSF | 1.28 ± 0.68a | 25.06 ± 12.59bcd | 11.39 ± 4.24ac | 13.80 ± 2.29bc | 40.38 ± 4.51d | 20.45 ± 3.50bc | 24.44 ± 5.15bcd | 11.30 ± 2.23bcd |
GM-CSF | 6.62 ± 2.31a | 22.41 ± 2.29bc | 20.15 ± 1.84b | 30.83 ± 5.85cd | 44.02 ± 4.48e | 32.71 ± 2.76cd | 37.76 ± 4.15de | 27.38 ± 4.46cd |
IFN-γ | 14.19 ± 3.16a | 76.07 ± 14.31ab | 51.22 ± 8.18a | 150.66 ± 30.78cd | 219.15 ± 44.86d | 136.96 ± 14.43bc | 160.27 ± 26.80cd | 120.45 ± 35.03bc |
KC | 9.95 ± 1.75a | 19.05 ± 3.24ab | 10.36 ± 1.51a | 22.66 ± 2.22b | 26.26 ± 3.91b | 22.89 ± 1.65b | 28.51 ± 3.82b | 20.39 ± 3.47ab |
MCP-1 | 109.21 ± 11.86a | 277.14 ± 23.85bc | 202.25 ± 18.47ab | 311.17 ± 36.45c | 440.78 ± 49.29d | 295.60 ± 33.14c | 327.16 ± 38.26c | 259.00 ± 40.22bc |
MIP-1α | 307.86 ± 44.49a | 583.64 ± 48.62b | 500.58 ± 38.00b | 641.07 ± 66.25bc | 813.92 ± 90.49c | 501.03 ± 68.81b | 672.14 ± 75.99bc | 522.25 ± 72.06b |
MIP-1β | 17.64 ± 8.90a | 97.42 ± 19.81bc | 85.99 ± 17.25c | 152.07 ± 30.82cd | 248.47 ± 22.27e | 165.79 ± 11.07d | 175.62 ± 25.75dbe | 173.97 ± 28.40dbe |
RANTES | 0.00 ± 0.00abc | 2.21 ± 1.14ac | 1.16 ± 0.96a | 5.20 ± 2.82abc | 4.79 ± 2.47abc | 15.41 ± 3.52b | 10.35 ± 2.82abc | 10.73 ± 4.03bc |
TNF-α | 79.49 ± 41.61a | 558.78 ± 154.41b | 560.13 ± 188.57b | 642.66 ± 169.61b | 985.75 ± 148.06b | 630.06 ± 43.70b | 630.40 ± 125.34b | 717.02 ± 173.20b |
E2 | 230.63 ± 40.27 | 274.75 ± 111.88 | 96.75 ± 15.47 | 159.81 ± 28.44 | 150.16 ± 27.68 | 123.11 ± 15.37 | 205.83 ± 23.55 | 129.20 ± 26.77 |
P4 | 206.17 ± 46.07ab | 106.89 ± 17.78a | 241.39 ± 59.96ab | 364.94 ± 58.13b | 158.10 ± 52.16a | 33.51 ± 5.28c | 130.08 ± 47.18ac | 243.94 ± 98.57ab |
PRL | 8.71 ± 4.72ab | 78.88 ± 46.34acd | 50.75 ± 19.27de | 298.00 ± 79.05f | 85.43 ± 17.26dfg | 77.38 ± 43.77acdeg | 1.14 ± 0.74b | 7.00 ± 2.76bce |