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Table 1 Cytokine and hormone concentrations throughout lactation

From: Bayesian modeling suggests that IL-12 (p40), IL-13 and MCP-1 drive murine cytokine networks in vivo

Mediator NC (n = 7) Day 1 (n = 8) Day 2 (n = 8) Day 4 (n = 8) Day 10 (n = 7) Day 16 (n = 8) Day 21 (n = 7) Day 24 (n = 7)
IL-1α 0.52 ± 0.41a 3.40 ± 1.35ab 2.20 ± 0.75ab 7.46 ± 2.78bc 12.32 ± 2.42c 15.48 ± 2.16c 15.06 ± 2.85c 13.16 ± 1.81c
IL-1β 34.83 ± 11.89 50.12 ± 14.37 55.17 ± 6.45 57.21 ± 10.81 74.76 ± 6.21 51.07 ± 6.09 83.24 ± 25.51 41.59 ± 8.66
IL-2 5.67 ± 1.41a 12.50 ± 2.43abc 10.87 ± 1.31ab 25.25 ± 3.68d 36.73 ± 6.09e 17.75 ± 2.77bcd 25.38 ± 4.81d 18.08 ± 3.49cd
IL-3 1.50 ± 0.04a 1.90 ± 0.21ab 2.17 ± 0.51ac 2.77 ± 0.96ad 6.48 ± 3.33def 3.75 ± 0.84bdef 3.95 ± 1.13af 5.77 ± 2.36bcef
IL-4 0.10 ± 0.03 0.21 ± 0.06 0.19 ± 0.03 0.24 ± 0.12 0.58 ± 0.13 0.22 ± 0.05 0.53 ± 0.25 0.36 ± 0.15
IL-5 3.98 ± 0.69a 8.48 ± 1.50ab 10.32 ± 1.01bc 16.79 ± 2.54d 21.43 ± 2.24d 16.13 ± 2.48cd 17.84 ± 2.98d 13.79 ± 2.12cd
IL-6 17.08 ± 7.19a 119.81 ± 25.30b 151.52 ± 56.55b 164.98 ± 37.82b 265.95 ± 40.50b 151.35 ± 20.92b 201.91 ± 51.93b 154.86 ± 41.57b
IL-9 159.93 ± 24.69a 278.68 ± 28.05bc 236.61 ± 18.92acd 396.55 ± 46.52be 387.07 ± 28.31ef 394.43 ± 38.41be 296.10 ± 37.38bde 180.05 ± 20.59a
IL-10 5.69 ± 2.78a 18.95 ± 6.92abc 15.56 ± 6.16ac 27.99 ± 5.74ad 109.05 ± 29.77d 31.03 ± 4.86cd 45.68 ± 12.24cd 105.96 ± 62.76bd
IL-12 (p40) 164.44 ± 16.75ab 137.59 ± 37.23abc 114.44 ± 8.51b 247.74 ± 31.16ac 213.84 ± 20.94ac 160.99 ± 27.04abc 232.08 ± 11.32cd 259.51 ± 28.02cd
IL-12 (p70) 42.34 ± 17.66a 316.15 ± 101.70bc 249.58 ± 46.91bd 682.30 ± 173.51be 1222.66 ± 326.6ef 786.09 ± 90.51ef 699.93 ± 84.99ce 912.65 ± 283.08cdf
IL-13 117.81 ± 28.60a 324.07 ± 40.21b 261.46 ± 33.82ab 416.84 ± 67.09b 650.45 ± 108.10ab 334.77 ± 54.77ab 447.35 ± 86.24b 307.99 ± 69.89b
IL-17 42.17 ± 11.33a 155.83 ± 54.39abc 243.46 ± 27.76bd 391.00 ± 62.99de 477.14 ± 51.54e 446.35 ± 26.19e 441.08 ± 66.12ce 424.34 ± 55.23e
Eotaxin 115.26 ± 54.35 462.25 ± 158.06 388.22 ± 111.37 349.13 ± 55.09 517.32 ± 104.37 470.79 ± 42.03 446.18 ± 50.47 444.59 ± 33.41
G-CSF 1.28 ± 0.68a 25.06 ± 12.59bcd 11.39 ± 4.24ac 13.80 ± 2.29bc 40.38 ± 4.51d 20.45 ± 3.50bc 24.44 ± 5.15bcd 11.30 ± 2.23bcd
GM-CSF 6.62 ± 2.31a 22.41 ± 2.29bc 20.15 ± 1.84b 30.83 ± 5.85cd 44.02 ± 4.48e 32.71 ± 2.76cd 37.76 ± 4.15de 27.38 ± 4.46cd
IFN-γ 14.19 ± 3.16a 76.07 ± 14.31ab 51.22 ± 8.18a 150.66 ± 30.78cd 219.15 ± 44.86d 136.96 ± 14.43bc 160.27 ± 26.80cd 120.45 ± 35.03bc
KC 9.95 ± 1.75a 19.05 ± 3.24ab 10.36 ± 1.51a 22.66 ± 2.22b 26.26 ± 3.91b 22.89 ± 1.65b 28.51 ± 3.82b 20.39 ± 3.47ab
MCP-1 109.21 ± 11.86a 277.14 ± 23.85bc 202.25 ± 18.47ab 311.17 ± 36.45c 440.78 ± 49.29d 295.60 ± 33.14c 327.16 ± 38.26c 259.00 ± 40.22bc
MIP-1α 307.86 ± 44.49a 583.64 ± 48.62b 500.58 ± 38.00b 641.07 ± 66.25bc 813.92 ± 90.49c 501.03 ± 68.81b 672.14 ± 75.99bc 522.25 ± 72.06b
MIP-1β 17.64 ± 8.90a 97.42 ± 19.81bc 85.99 ± 17.25c 152.07 ± 30.82cd 248.47 ± 22.27e 165.79 ± 11.07d 175.62 ± 25.75dbe 173.97 ± 28.40dbe
RANTES 0.00 ± 0.00abc 2.21 ± 1.14ac 1.16 ± 0.96a 5.20 ± 2.82abc 4.79 ± 2.47abc 15.41 ± 3.52b 10.35 ± 2.82abc 10.73 ± 4.03bc
TNF-α 79.49 ± 41.61a 558.78 ± 154.41b 560.13 ± 188.57b 642.66 ± 169.61b 985.75 ± 148.06b 630.06 ± 43.70b 630.40 ± 125.34b 717.02 ± 173.20b
E2 230.63 ± 40.27 274.75 ± 111.88 96.75 ± 15.47 159.81 ± 28.44 150.16 ± 27.68 123.11 ± 15.37 205.83 ± 23.55 129.20 ± 26.77
P4 206.17 ± 46.07ab 106.89 ± 17.78a 241.39 ± 59.96ab 364.94 ± 58.13b 158.10 ± 52.16a 33.51 ± 5.28c 130.08 ± 47.18ac 243.94 ± 98.57ab
PRL 8.71 ± 4.72ab 78.88 ± 46.34acd 50.75 ± 19.27de 298.00 ± 79.05f 85.43 ± 17.26dfg 77.38 ± 43.77acdeg 1.14 ± 0.74b 7.00 ± 2.76bce
  1. Cytokine, E2 (pg/ml), PRL and P4 (ng/ml) concentrations throughout lactation (mean ± SEM). Groups that do not share a common superscript letter are significantly different from each other (P < 0.05); NC - naturally cycling