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Table 3 Changes in conditional probability associated with perturbation of PRL and structural hubs

From: Bayesian modeling suggests that IL-12 (p40), IL-13 and MCP-1 drive murine cytokine networks in vivo

Cytokine Low Medium High
PRL 0.065 0.692 0.243
P4 0.066 0.786 0.148
P4-PRL 0.778 0.111 0.111
P4-PRL+IL-13 0.778 0.111 0.111
P4-PRL+MCP-1 0.778 0.111 0.111
P4-PRL+IL-13+MCP-1 0.778 0.111 0.111
IL-13 0.400 0.499 0.101
IL-13-PRL 0.379 0.348 0.272
IL-13-PRL+IL-13 0.000 0.000 1.000
IL-13-PRL+MCP-1 0.379 0.348 0.272
IL-13-PRL+IL-13+MCP-1 0.000 0.000 1.000
IL-2 0.274 0.602 0.124
IL-2-PRL 0.274 0.481 0.246
IL-2-PRL+IL-13 0.111 0.111 0.778
IL-2-PRL+MCP-1 0.274 0.481 0.246
IL-2-PRL+IL-13+MCP-1 0.111 0.111 0.778
MCP-1 0.431 0.458 0.111
MCP-1-PRL 0.418 0.386 0.196
MCP-1-PRL+IL-13 0.200 0.229 0.571
MCP-1-PRL+MCP-1 0.000 0.000 1.000
MCP-1-PRL+IL-13+MCP-1 0.000 0.000 1.000
GM-CSF 0.359 0.526 0.115
GM-CSF-PRL 0.353 0.469 0.178
GM-CSF-PRL+IL-13 0.225 0.316 0.458
GM-CSF-PRL+MCP-1 0.111 0.111 0.778
GM-CSF-PRL+IL-13+MCP-1 0.111 0.111 0.778
MIP-1α 0.235 0.687 0.078
MIP-1α-PRL 0.250 0.644 0.106
MIP-1α-PRL+IL-13 0.250 0.521 0.229
MIP-1α-PRL+MCP-1 0.270 0.360 0.370
MIP-1α-PRL+IL-13+MCP-1 0.270 0.360 0.370
MIP-1β 0.607 0.208 0.186
MIP-1β-PRL 0.570 0.224 0.205
MIP-1β-PRL+IL-13 0.434 0.293 0.273
MIP-1β-PRL+MCP-1 0.321 0.357 0.321
MIP-1β-PRL+IL-13+MCP-1 0.321 0.357 0.321
KC 0.165 0.706 0.129
KC-PRL 0.168 0.692 0.140
KC-PRL+IL-13 0.183 0.635 0.181
KC-PRL+MCP-1 0.201 0.569 0.230
KC-PRL+IL-13+MCP-1 0.201 0.569 0.230
IL-1α 0.626 0.223 0.151
IL-1α-PRL 0.605 0.230 0.165
IL-1α-PRL+IL-13 0.528 0.256 0.216
IL-1α-PRL+MCP-1 0.465 0.281 0.254
IL-1α-PRL+IL-13+MCP-1 0.465 0.281 0.254
IL-10 0.648 0.230 0.122
IL-10-PRL 0.622 0.245 0.133
IL-10-PRL+IL-13 0.526 0.301 0.173
IL-10-PRL+MCP-1 0.448 0.348 0.204
IL-10-PRL+IL-13+MCP-1 0.448 0.348 0.204
IFN-γ 0.504 0.299 0.197
IFN-γ-PRL 0.465 0.299 0.236
IFN-γ-PRL+IL-13 0.325 0.337 0.338
IFN-γ-PRL+MCP-1 0.352 0.325 0.323
IFN-γ-PRL+IL-13+MCP-1 0.316 0.341 0.343
IL-5 0.517 0.327 0.156
IL-5-PRL 0.487 0.336 0.177
IL-5-PRL+IL-13 0.377 0.386 0.237
IL-5-PRL+MCP-1 0.398 0.375 0.228
IL-5-PRL+IL-13+MCP-1 0.370 0.390 0.240
IL-17 0.513 0.391 0.096
IL-17-PRL 0.486 0.406 0.108
IL-17-PRL+IL-13 0.390 0.467 0.144
IL-17-PRL+MCP-1 0.407 0.454 0.138
IL-17-PRL+IL-13+MCP-1 0.384 0.470 0.146
IL-6 0.608 0.306 0.086
IL-6-PRL 0.585 0.319 0.096
IL-6-PRL+IL-13 0.506 0.371 0.123
IL-6-PRL+MCP-1 0.521 0.361 0.119
IL-6-PRL+IL-13+MCP-1 0.501 0.374 0.124
RANTES 0.483 0.276 0.241
RANTES-PRL 0.454 0.287 0.259
RANTES-PRL+IL-13 0.373 0.322 0.305
RANTES-PRL+MCP-1 0.328 0.347 0.326
RANTES-PRL+IL-13+MCP-1 0.327 0.347 0.326
TNF-α 0.372 0.317 0.311
TNF-α-PRL 0.364 0.321 0.316
TNF-α-PRL+IL-13 0.346 0.328 0.325
TNF-α-PRL+MCP-1 0.341 0.331 0.329
TNF-α-PRL+IL-13+MCP-1 0.340 0.331 0.329
  1. Conditional probabilities are given to each of three bins (low, medium and high). Highest conditional probability values in any given bin indicate a greater likelihood of the relevant mediator’s concentration being in that concentration bin. The large font denotes the node of interest; small font indicates the perturbed parent node; a ‘-’ sign indicates perturbation by reducing concentration while a ‘+’ sign indicates perturbation by increasing concentration