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Fig. 3 | BMC Systems Biology

Fig. 3

From: Integrating transcriptional and protein interaction networks to prioritize condition-specific master regulators

Fig. 3

Driver TFs have high degree in inferred regulatory network associated with rapamycin response. a Receiver-operator characteristic (ROC) curves showing performance of two different measures – degree in GMIT transcriptional network and differential expression after addition of rapamycin for 50 minutes – in identifying driver TFs. P-values are computed using Wilcoxon test. b Bar graphs show the odds ratio for the overlap between driver TFs and the top 10, 20 and 30 % of TFs ranked by degree or differential expression. c Transcriptional network inferred by GMIT in rapamycin-perturbed yeast. Only TFs and their interactions are shown. Red nodes denote rapamycin driver genes. The size of the node is proportional to its degree in the full network, including all target genes

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BMC Systems Biology

ISSN: 1752-0509

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