Fig. 8

Cancer drivers with high combined network score interact with proteins enriched in cellular localization or developmental pathways. Heatmap shows the ranks of cancer drivers that were among the top 10 % TFs according to either the transcriptional network degree, the protein interaction degree, or the combined network score, with red depicting higher ranks and blue depicting lower ranks. Network diagram shows all direct protein interactors of the cancer driver TFs that had a higher rank in the combined network score than in either individual network alone. Edges represent evidence of direct protein interaction from yeast two-hybrid experiments