Table 1 Top thirty viral oncogene-associated TFs ranked by combined network score

1

TCF4

132

41

8.5

2

TCF12

29

43

11

Sanger cancer gene

3

TFCP2

47

32

16.5

Oncogene in hepatocellular carcinoma (HCC); enhances angiogenesis and chemoresistance [39, 40]

4

ZBTB7B

12

43

17.5

5

SP4

11

46

17.75

6

IKZF1

57

28

19.25

Sanger cancer gene

7

MYOG

11

42

21.5

8

SMAD3

8

34

31.5

Plays role in carcinogenesis and metastasis [41–43]

9

BCL6B

14

20

32.75

Tumor suppressor in colorectal cancer and HCC [45, 46]

10

WT1

3

43

39.5

Sanger cancer gene

11

LMO2

66

12

40.25

Sanger cancer gene

12

SP2

3

36

45.5

13

CREB5

35

11

48.25

14

TCF3

2

51

48.5

Sanger cancer gene

15

MXI1

11

13

49.5

Potential tumor suppressor in neuroblastoma and renal cancer [47, 48]

16

NRF1

4

20

50.5

17

CREB3L1

16

11

52

Sanger cancer gene

18

USF1

5

15

54.5

19

GABPB1

10

12

56

20

NHLH1

2

38

56.25

21

MAX

3

20

57.25

Sanger cancer gene

22

NR1H3

3

17

61.75

23

USF2

3

15

65

24

SMAD4

2

20

69.25

Sanger cancer gene

25

STRA13

2

20

69.25

26

NR1H2

2

18

72

27

EBF1

2

15

77

Sanger cancer gene

28

TFAP4

3

9

82.5

Linked to non-small cell lung cancer and colorectal cancer [50–52]

29

RXRB

2

12

85.25

30

NFE2L2

2

12

85.25

Sanger cancer gene