Fig. 9

Time course clusters in BDL. Six time course clusters (a-f corresponding to cluster 1-6) resulting from hierarchical clustering (see Fig. 7). The mean cluster time course (averaged over all factors and repeats) is depicted in blue, all representatives of the respective cluster in grey. The shaded blue area corresponds to the standard deviation between the mean time courses of the representatives in the cluster. The top correlations between the mean cluster time course and factors in the cluster are listed above the time course (color coding analog to Fig. 8c with positive correlations in blue and negative correlations in red) with histological factors marked with H, immunostainings with A, and biochemical factors with B. The cluster members are fully enumerated for all clusters with exception of cluster 4. The full set of members and respective correlation to the mean cluster time course for cluster 4 are: Timp1 (0.94), bilirubin (B 0.92), Ccr2 (0.92), CTGF (A 0.91), Tgfbr2 (0.89), α-SMA (A 0.89), Ccl5 (0.88), Tgfb1 (0.88), Ccl3 (0.87), Tnc (0.87), Cd14 (0.87), Ccl2 (0.86), Cd86 (0.86), Pdgfb (0.86), Col1a1 (0.86), Cxcl3 (0.86), Ccl4 (0.85), Cxcl5 (0.85), Il10ra (0.85), Col3a1 (0.85), Il10rb (0.84), Ccl7 (0.82), Cd69 (0.82), Ifnar1 (0.82), Tnf (0.82), Osm (0.81), Sparc (0.8), Il6 (0.8), Tnfrsf1b (0.8), Cxcr2 (0.78), Il1b (0.78), Timp2 (0.77), Ifnar2 (0.77), Ccr5 (0.77), Il10 (0.76), Osmr (0.75), Gsta2 (0.74), Il4 (0.71), Ifng (0.71), Ccl8 (0.71), Hgf (0.7), Bak1 (0.7), Mrc1 (0.69), Tgfb2 (0.69), Ccr3 (0.68), Actb (0.68), S100a4 (A 0.66), Il13 (0.66), Met (0.66), bile infarcts (H 0.65), Il6st (0.63), Tnfrsf1a (0.63), Mki67 (0.62), Birc5 (0.6), Ctgf (0.58), BEC (H 0.56), Bax (0.56), Notch1 (0.54), Cxcr1 (0.51), Gstm1 (0.45), Cdh1 (0.42)