Fig. 4
From: Tip cell overtaking occurs as a side effect of sprouting in computational models of angiogenesis
Dll4 patterning by tip cell selection. a Checkerboard-like patterning of tip and stalk cells in a simulation of the contact inhibition model. The red color indicates high levels of Dll4 (tip cells) and blue indicates low levels of Dll4. b Checkerboard-like patterning of tip and stalk cells in a simulation of the cell elongation model. Figures (c–j) are images from a simulation of the contact inhibition model. c–e Enlarged view of a sprout in which branching occurs over time, at the location of the white circle in panel (c). f–h Enlarged view of two fusing sprouts (anastomosis) in time, indicated by the white circle in panel (f). i–k Enlarged view of a sprout in which tip cell overtaking occurs in time at the location of the white circle in panel (i). The cell annotated with a square overtakes the tip cell position from the cell annotated with a star