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Fig. 6 | BMC Systems Biology

Fig. 6

From: Tracing regulatory routes in metabolism using generalised supply-demand analysis

Fig. 6

Rate characteristic plots of the reaction blocks of ϕ N in the pyruvate branch model. a The fluxes of the demand blocks 2, 6, 11 and 13, and the supply blocks 1 and 3 of ϕ N . The unlabelled dashed curves represent the total supply (blue) and demand (green). b The rate characteristic plot of the ϕ N -demand block 6 with partial and total response coefficients indicated as lines intersecting the J 6-curve at the steady-state value of ϕ N . Partial response coefficients (solid lines) indicate the relative contribution of each respective route of interaction of ϕ N with the reaction block 6 towards the total response coefficient (dashed line). Note that \(\protect \phantom {\dot {i}\!}{{~\!\!}^{v_{11}}{R^{J_{6}}_{\phi _{N}}}}\) and \(\protect \phantom {\dot {i}\!}{{~\!\!}^{v_{13}}{R^{J_{6}}_{\phi _{N}}}}\) were omitted due to their zero contributions towards \(\protect \phantom {\dot {i}\!}{R^{J_{6}}_{\phi _{N}}}\). The steady-state value of ϕ N is indicated as a vertical dotted line in both (a) and (b) (see Table 1)

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