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Table 3 Analysis of the distribution of flux control between the supply and demand blocks of ASA

From: Tracing regulatory routes in metabolism using generalised supply-demand analysis

  Reference AKI knockout AKII knockout AKI, AKII
     knockout
\({R^{{J}_{5}}_{\textit {ASA}}}\) −1.04 −0.95 −0.66 −0.46
\({R^{{J}_{8}}_{\textit {ASA}}}\) 0.52 0.53 0.59 0.61
\({R^{{J}_{16}}_{\textit {ASA}}}\) 0.14 0.14 0.14 0.15
|R ASA J 5/R ASA J 8 | 2.01 1.80 1.13 0.76
|R ASA J 5/R ASA J 16 | 7.56 6.85 4.60 3.17
  1. Total response coefficients of J 5, J 8 and J 16 towards ASA at the steady-state and the distribution of flux control between the supply and demand blocks according to the principle illustrated in Eq. 6 are presented. Control analysis was performed for the reference model and each of the knockouts with the concentration of the linking metabolite between supply and demand fixed at the steady-state value in each case (see Table S2 in Additional file 6)