Tracing regulatory routes in metabolism using generalised supply-demand analysis

BMC Systems Biology

Table 3 Analysis of the distribution of flux control between the supply and demand blocks of ASA

	Reference	AKI knockout	AKII knockout	AKI, AKII
				knockout
\({R^{{J}_{5}}_{\textit {ASA}}}\)	−1.04	−0.95	−0.66	−0.46
\({R^{{J}_{8}}_{\textit {ASA}}}\)	0.52	0.53	0.59	0.61
\({R^{{J}_{16}}_{\textit {ASA}}}\)	0.14	0.14	0.14	0.15
\|R ASA J ₅/R ASA J ₈ \|	2.01	1.80	1.13	0.76
\|R ASA J ₅/R ASA J ₁₆ \|	7.56	6.85	4.60	3.17

Total response coefficients of J ₅, J ₈ and J ₁₆ towards ASA at the steady-state and the distribution of flux control between the supply and demand blocks according to the principle illustrated in Eq. 6 are presented. Control analysis was performed for the reference model and each of the knockouts with the concentration of the linking metabolite between supply and demand fixed at the steady-state value in each case (see Table S2 in Additional file 6)

ISSN: 1752-0509