Fig. 2
From: Prediction of drugs having opposite effects on disease genes in a directed network
Overview of PDOD. a Integrating pathways whose edges have ‘effect type’ and ‘effect direction’ information. b Mapping drug-drug target interactions on an integrated pathway with their ‘effect type’ and ‘effect direction’. c Mapping disease genes with their regulated states in patients. d Predicting drugs having opposite effects on states of disease genes in disease states based on shortest paths