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Table 1 Top 10 ranked drugs in PDD and their potentiality for the therapy of diseases

From: Prediction of drugs having opposite effects on disease genes in a directed network

Disease (MeSH ID)

Drug (DrugBank ID)

Description in DrugBank

Supporting evidence from literature

OG (D009837)

Tetracycline (DB00759)

Bacterial infections

[27]

TC (D013964)

Clomifene (DB00882)

Female infertility due to anovulation

n/a

TC (D013964)

Fulvestrant (DB00947)

Metastatic breast cancer

[28]

TC (D013964)

Ospemifene (DB04938)

Dyspareunia

n/a

TC (D013964)

Cetuximab (DB00002)

Metastatic colorectal cancer

[29], [30]

TC (D013964)

Gefitinib (DB00317)

Certain types of cancer

[31]–[33]

TC (D013964)

Erlotinib (DB00530)

Non-small cell lung cancer

[34]–[36]

TC (D013964)

Panitumumab (DB01269)

Antineoplastic agent

[36]

AML (D015470)

Mecasermin (DB01277)

Primary IGF 1 deficiency

n/a

TC (D013964)

Purvalanol (DB02733)

n/a

n/a