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Table 3 Distribution of the top 50 functional domains covering ubiquitination sites

From: A new scheme to discover functional associations and regulatory networks of E3 ubiquitin ligases

No.

Domain (InterPro) ID

Domain (InterPro) terms

Number of sites

% Total

1

IPR001039

MHC class I, alpha chain, alpha1/alpha2

1625

3.6574 %

2

IPR003597

Immunoglobulin C1-set

1321

2.9732 %

3

IPR001680

WD40 repeat

1043

2.3475 %

4

IPR002017

Spectrin repeat

1012

2.2777 %

5

IPR010579

MHC class I, alpha chain, C-terminal

729

1.6408 %

6

IPR003961

Fibronectin, type III

469

1.0556 %

7

IPR000504

RNA recognition motif domain

419

0.9431 %

8

IPR000719

Protein kinase, catalytic domain

338

0.7607 %

9

IPR013098

Immunoglobulin I-set

232

0.5222 %

10

IPR020683

Ankyrin repeat-containing domain

230

0.5177 %

11

IPR017868

Filamin/ABP280 repeat-like

212

0.4772 %

12

IPR006209

EGF-like domain

179

0.4029 %

13

IPR001715

Calponin homology domain

177

0.3984 %

14

IPR010630

Neuroblastoma breakpoint family (NBPF) domain

168

0.3781 %

15

IPR001452

Src homology-3 domain

167

0.3759 %

16

IPR006652

Kelch repeat type 1

158

0.3556 %

17

IPR000408

Regulator of chromosome condensation, RCC1

157

0.3534 %

18

IPR000225

Armadillo

156

0.3511 %

19

IPR004088

K Homology domain, type 1

154

0.3466 %

20

IPR001650

Helicase, C-terminal

146

0.3286 %

21

IPR002126

Cadherin

145

0.3264 %

22

IPR000048

IQ motif, EF-hand binding site

143

0.3219 %

23

IPR000083

Fibronectin, type I

143

0.3219 %

24

IPR000626

Ubiquitin

142

0.3196 %

25

IPR000008

C2 calcium-dependent membrane targeting

135

0.3038 %

26

IPR001806

Small GTPase superfamily

125

0.2813 %

27

IPR001245

Serine-threonine/tyrosine-protein kinase catalytic domain

125

0.2813 %

28

IPR000433

Zinc finger, ZZ-type

123

0.2768 %

29

IPR001478

PDZ domain

122

0.2746 %

30

IPR001849

Pleckstrin homology domain

120

0.2701 %

31

IPR011545

DNA/RNA helicase, DEAD/DEAH box type, N-terminal

112

0.2521 %

32

IPR019787

Zinc finger, PHD-finger

111

0.2498 %

33

IPR001440

Tetratricopeptide TPR-1

111

0.2498 %

34

IPR001202

WW/Rsp5/WWP

110

0.2476 %

35

IPR018108

Mitochondrial substrate/solute carrier

110

0.2476 %

36

IPR001781

Zinc finger, LIM-type

106

0.2386 %

37

IPR001101

Plectin repeat

104

0.2341 %

38

IPR002049

EGF-like, laminin

100

0.2251 %

39

IPR002429

Cytochrome c oxidase subunit II C-terminal

96

0.2161 %

40

IPR011759

Cytochrome C oxidase subunit II, transmembrane domain

96

0.2161 %

41

IPR003439

ABC transporter-like

91

0.2048 %

42

IPR001487

Bromodomain

91

0.2048 %

43

IPR018502

Annexin repeat

88

0.1981 %

44

IPR000980

SH2 domain

86

0.1936 %

45

IPR003008

Tubulin/FtsZ, GTPase domain

77

0.1733 %

46

IPR001421

ATPase, F0 complex, subunit 8, mitochondrial, Metazoan

75

0.1688 %

47

IPR013069

BTB/POZ

75

0.1688 %

48

IPR003959

ATPase, AAA-type, core

74

0.1666 %

49

IPR007087

Zinc finger, C2H2

74

0.1666 %

50

IPR000197

Zinc finger, TAZ-type

74

0.1666 %