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Table 3 Distribution of the top 50 functional domains covering ubiquitination sites

From: A new scheme to discover functional associations and regulatory networks of E3 ubiquitin ligases

No. Domain (InterPro) ID Domain (InterPro) terms Number of sites % Total
1 IPR001039 MHC class I, alpha chain, alpha1/alpha2 1625 3.6574 %
2 IPR003597 Immunoglobulin C1-set 1321 2.9732 %
3 IPR001680 WD40 repeat 1043 2.3475 %
4 IPR002017 Spectrin repeat 1012 2.2777 %
5 IPR010579 MHC class I, alpha chain, C-terminal 729 1.6408 %
6 IPR003961 Fibronectin, type III 469 1.0556 %
7 IPR000504 RNA recognition motif domain 419 0.9431 %
8 IPR000719 Protein kinase, catalytic domain 338 0.7607 %
9 IPR013098 Immunoglobulin I-set 232 0.5222 %
10 IPR020683 Ankyrin repeat-containing domain 230 0.5177 %
11 IPR017868 Filamin/ABP280 repeat-like 212 0.4772 %
12 IPR006209 EGF-like domain 179 0.4029 %
13 IPR001715 Calponin homology domain 177 0.3984 %
14 IPR010630 Neuroblastoma breakpoint family (NBPF) domain 168 0.3781 %
15 IPR001452 Src homology-3 domain 167 0.3759 %
16 IPR006652 Kelch repeat type 1 158 0.3556 %
17 IPR000408 Regulator of chromosome condensation, RCC1 157 0.3534 %
18 IPR000225 Armadillo 156 0.3511 %
19 IPR004088 K Homology domain, type 1 154 0.3466 %
20 IPR001650 Helicase, C-terminal 146 0.3286 %
21 IPR002126 Cadherin 145 0.3264 %
22 IPR000048 IQ motif, EF-hand binding site 143 0.3219 %
23 IPR000083 Fibronectin, type I 143 0.3219 %
24 IPR000626 Ubiquitin 142 0.3196 %
25 IPR000008 C2 calcium-dependent membrane targeting 135 0.3038 %
26 IPR001806 Small GTPase superfamily 125 0.2813 %
27 IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain 125 0.2813 %
28 IPR000433 Zinc finger, ZZ-type 123 0.2768 %
29 IPR001478 PDZ domain 122 0.2746 %
30 IPR001849 Pleckstrin homology domain 120 0.2701 %
31 IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal 112 0.2521 %
32 IPR019787 Zinc finger, PHD-finger 111 0.2498 %
33 IPR001440 Tetratricopeptide TPR-1 111 0.2498 %
34 IPR001202 WW/Rsp5/WWP 110 0.2476 %
35 IPR018108 Mitochondrial substrate/solute carrier 110 0.2476 %
36 IPR001781 Zinc finger, LIM-type 106 0.2386 %
37 IPR001101 Plectin repeat 104 0.2341 %
38 IPR002049 EGF-like, laminin 100 0.2251 %
39 IPR002429 Cytochrome c oxidase subunit II C-terminal 96 0.2161 %
40 IPR011759 Cytochrome C oxidase subunit II, transmembrane domain 96 0.2161 %
41 IPR003439 ABC transporter-like 91 0.2048 %
42 IPR001487 Bromodomain 91 0.2048 %
43 IPR018502 Annexin repeat 88 0.1981 %
44 IPR000980 SH2 domain 86 0.1936 %
45 IPR003008 Tubulin/FtsZ, GTPase domain 77 0.1733 %
46 IPR001421 ATPase, F0 complex, subunit 8, mitochondrial, Metazoan 75 0.1688 %
47 IPR013069 BTB/POZ 75 0.1688 %
48 IPR003959 ATPase, AAA-type, core 74 0.1666 %
49 IPR007087 Zinc finger, C2H2 74 0.1666 %
50 IPR000197 Zinc finger, TAZ-type 74 0.1666 %