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Table 1 New associated pathways and SNPs under ethanol condition

From: A network based covariance test for detecting multivariate eQTL in saccharomyces cerevisiae

Pathways

Associated markers

Glycolysis/Gluconeogenesis

g O L02(10)

Synthesis and degradation of ketone bodies

Y L R257W (10),Y L R261C (10)

Steroid biosynthesis

Y E L021W L , Y F R035C L ,

 

Y J L001W L , Y J R006W L,(10),

 

Y J L007C L,(10),

Valine, leucine and isoleucine degradation

Y O R006C L , N O R005W L,(10),

 

Y O R051C L,(10), Y O R076C L,(10)

Valine, leucine and isoleucine

N L R116W L,(10), Y O R076C L ,

biosynthesis

Y C L023C (10), Y L R257W (10)

Histidine metabolism

g O L02L,(10), Y O R025W (10)

Tyrosine metabolism

Y F L019C L , g O L02L,(10)

Phenylalanine metabolism

g O L02L,(10)

beta-Alanine metabolism

g O L02L,(10)

Taurine and hypotaurine metabolism

g O L02(10)

Selenocompound metabolism

Y O R006C L,(10), Y O R019W L,(10),

 

Y O R025W L,(10), N O R005W L,(10)

Purine metabolism

N N L035W (1)

Cyanoamino acid metabolism

Y L R027C (1)

Arachidonic acid metabolism

g P L09(1)

Linoleic acid metabolism

Y F L029C L,(1),(10), Y F L019C (1)

Glyoxylate and dicarboxylate metabolism

N N L035W (1), Y N L074C (1)

Porphyrin and chlorophyll metabolism

N B R008W (1)

Sphingolipid metabolism

Y H L047C L

Pantothenate and CoA biosynthesis

Y G L053W L , N L R116W L,(10)

Terpenoid backbone biosynthesis

Y J L007C L,(10), Y J L001W L,(10),

 

Y J R006W L,(10), N J R006C L,(10)

Sesquiterpenoid and triterpenoid

Y O R334W L , Y O R343C L ,

biosynthesis

 
 

Y L R261C (10), N L R116W (10),

 

Y L R257W (10)

Metabolic pathways

Y I L078W (10), Y L R257W (10),

 

Y L R308W (10), N N L035W (10),

 

g O L02(10), Y O R006C (10),

 

Y O R051C (10),Y O R019W (10),

 

Y N L066W (10),Y L R261C (10)

Biosynthesis of secondary metabolites

Y O R025W (10), Y O R063W (10)

Carbon metabolism

Y O R019W (10)

2-Oxocarboxylic acid metabolism

Y L R261C L,(10), Y L R308W L,(10),

 

Y C L022C (10), Y L R265C (10),

 

N L R116W (10),Y L R322W L

mRNA surveillance pathway

Y O R072W L

Mismatch repair

g K R08L

Non-homologous end

Y G R006W L

Biosynthesis of amino acids

g O L02(10)

MAPK signaling pathway

Y D R164C (10), g D R10(10)

  1. L means detected by covariance test, (1) means detected by kernel covariance test with parameter 1 and (10) means detected by kernel covariance test with parameter 10. The FDR of the covariance test, kernel covariance test with parameter 1 and kernel covariance test with parameter 10 are 0.25, 0.33 and 0.25 respectively. The FWER of the test by Tony Cai is 0.2