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Table 2 New associated pathways and SNPs under glucose condition

From: A network based covariance test for detecting multivariate eQTL in saccharomyces cerevisiae

Pathways

Associated markers

Synthesis and degradation of ketone bodies

g J L07(10)

Inositol phosphate metabolism

Y B R259W (10)

Riboflavin metabolism

Y M L056C (10)

Fatty acid degradation

Y B R045C (1)

Cysteine and methionine metabolism

Y G L195W (1)

Valine, leucine and isoleucine biosynthesis

Y C L025C L ,N G R093C L

 

Y O R253W L ,Y O R274W L

 

Y O R326W L ,Y O R334W L

 

Y O R343C L ,Y C L022C (1)

Phenylalanine metabolism

Y J R040W L ,Y O L123W L

 

Y O L118C L ,Y O L106W L

 

Y O L093W L ,Y O L088C L

 

g O L02L,(1)

beta-Alanine metabolism

Y B R271W L ,g O L02L,(1)

 

N J R007C L ,Y O L106W L

Arachidonic acid metabolism

Y I R022W L,(1)

Vitamin B6 metabolism

Y K L118W (1)

Porphyrin and chlorophyll metabolism

Y M L071C (1),g F L02L

Degradation of aromatic compounds

Y M R316C L,(1),Y M R316C L

ABC transporters

Y B R131W L,(1),Y B R137W L

Glycolysis/Gluconeogenesis

Y J R071W L

Pentose phosphate pathway

N O L043W L , Y O L151W L

 

Y O L123W L , Y O L094C L

 

Y O L093W L , Y O L088C L

 

g O L02L

Pentose and glucuronate interconversions

Y G L263W L

Purine metabolism

Y L R140W L

Pyrimidine metabolism

Y B L010C L , Y G L217C L

Glycine, serine and threonine metabolism

Y C L065W L , Y J R038C L

Lysine biosynthesis

Y B R087W L

Histidine metabolism

Y B R271W L , N J R007C L

 

Y J R040W L , Y J R057W L

 

Y O L106W L , Y O L093W L ,

 

g O L02L,(1)

Tyrosine metabolism

Y O L123W L , Y O L106W L

 

Y O L094C L , g O L02L,(1)

Cyanoamino acid metabolism

Y D R351W L

Starch and sucrose metabolism

Y E R095W L ,Y E R116C L

Linoleic acid metabolism

N D R174C L

Butanoate metabolism

Y B R271W L

Pantothenate and CoA biosynthesis

Y O R274W L

Lipoic acid metabolism

g L L01L ,Y N L158W L

Folate biosynthesis

N M L013W L ,Y N L066W L ,Y N L050C L

Sesquiterpenoid and triterpenoid biosynthesis

Y M R084W L

Aminoacyl-tRNA biosynthesis

Y C L065W L ,Y C L047C L

 

Y C L039W L ,N J R007C L ,Y N L010W L

Biosynthesis of unsaturated fatty acids

Y F L029C L

Metabolic pathways

Y C L065W L ,Y J R071W L

Biosynthesis of secondary metabolites

Y J R038C6L

Biosynthesis of amino acids

Y J R071W L ,Y O L123W L

 

Y O L118C L ,Y O L106W L

 

Y O L094C L ,Y O L093W L

 

Y O L088C L ,g O L02L

Ribosome

Y A R035W L ,Y J L026W L

RNA transport

Y B L010C L

RNA polymerase

Y L R140W L

Proteasome

Y B L010C L

Phosphatidylinositol signaling system

Y B R045C L

Meiosis - yeast

Y O L106W L

  1. L means detected by covariance test, (1) means detected by kernel covariance test with parameter 1 and (10) means detected by kernel covariance test with parameter 10. The FDR of the covariance test, kernel covariance test with parameter 1 and kernel covariance test with parameter 10 are 0.20, 0.24 and 0.33 respectively. The FWER of the test by Tony Cai is 0.2