Generalized logical model based on network topology to capture the dynamical trends of cellular signaling pathways

Table 1 Comparison of the computational time required for SimBoolNet, GINsim and the proposed model

Number of nodes/edges	SimBoolNet	GINsim	Our model
5/13	9.51s	< 0.1s	0.09s
35/57	10.73s	< 0.1s	0.43s
500/6124	72.88s	Not applicable	10.68s

Three networks are employed for simulation, where the numbers of the nodes/edges are 5/13, 35/57 and 500/6124, respectively. The simulation using GINsim on the third network could not finish within endurable time (hence marked “Not applicable”)

ISSN: 1752-0509