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Table 3 Inputs of the simulation in section “Model comparison and validation with real data”

From: Generalized logical model based on network topology to capture the dynamical trends of cellular signaling pathways

 

EGFR

TNFR

DNA damage

Control

+0.5

+0.5

random value

EGFR inhibitor

–1

+0.5

random value

DNA damage stimuli

random value

+0.5

+1

Both drugs

–1

+0.5

+1

  1. The symbols ‘+’ and ‘–’ represent the perturbation types, i.e., activation and inhibition. The columns are the input nodes of simulation and the rows are various conditions including the treatments of biological experiments with drugs corresponding to wet-lab experiments in [18]