Table 3 SNPs present in each of the component phenotypes in compound sets, with composite p-value computed from individual phenotype components, pattern p-value computed on the compound phenotype members, odds ratio logistic regression associations GWAS for each phenotype set. Entries show locus w/ minor allele, and the odds ratio, 95 % confidence interval, and p-value for the SNP vs. the phenotype
Locus | Composite | Pattern | DxT2D | DxHT | DxCAD ∧ |
|---|---|---|---|---|---|
Minor Allele | p-value | p-value | Age ≥ 60 | ||
rs12101936 | 1.079×10−9 | 4.961×10−5 | 0.76 | 0.78 | 0.80 |
A | (0.64–0.89) | (0.67–0.90) | (0.69–0.93) | ||
0.000628 | 0.000615 | 0.002796 | |||
rs17107637 | 1.872×10−8 | 0.002181 | 1.41 | 1.37 | 1.29 |
G | (1.14–1.75) | (1.13–1.67) | (1.06–1.57) | ||
0.00135 | 0.00140 | 0.00992 | |||
rs3759658 | 8.914×10−8 | 0.0304 | 1.34 | 1.33 | 1.35 |
A | (1.08–1.66) | (1.09–1.61) | (1.11–1.65) | ||
0.00733 | 0.00455 | 0.00267 | |||
rs6926556 | 9.205×10−9 | 0.0341 | 0.74 | 0.72 | 0.76 |
C | (0.60–0.91) | (0.60–0.86) | (0.63–0.92) | ||
0.00438 | 0.000457 | 0.00460 | |||
rs8113086 | 2.853×10−7 | 0.0936 | 0.75 | 0.77 | 0.75 |
T | (0.60–0.93) | (0.64–0.93) | (0.62–0.92) | ||
0.00841 | 0.00760 | 0.00447 | |||
rs878643 | 4.254×10−8 | 0.04394 | 0.764 | 0.800 | 0.819 |
A | (0.65–0.90) | (0.69–0.93) | (0.70–0.96) | ||
0.00841 | 0.00760 | 0.00447 | |||
rs11880382 | 1.518×10−7 | 0.005167 | 0.733 | 0.901 | 0.889 |
C | (0.64–0.84) | (0.79–1.03) | (0.78–1.01) | ||
1.669×10−5 | 0.118 | 0.077 | |||
rs2088354 | 3.133×10−8 | 0.0144 | 1.679 | 1.357 | 1.175 |
T | (1.31–2.15) | (1.09–1.68) | (0.95–1.46) | ||
3.856×10−5 | 0.00557 | 0.146 | |||
rs2992100 | 4.162×10−8 | 0.06262 | 0.559 | 0.772 | 1.282 |
A | (0.43–0.73) | (0.60–0.99) | (1.00–1.64) | ||
2.35×10−5 | 0.0379 | 0.0468 | |||
rs3781788 | 4.837×10−8 | 0.001568 | 1.907 | 1.015 | 1.436 |
T | (1.44–2.52) | (0.77–1.34) | (1.09–1.89) | ||
5.527×10−6 | 0.913 | 0.00959 | |||
rs6080252 | 6.587×10−8 | 0.002838 | 1.623 | 1.303 | 1.279 |
A | (1.28–2.06) | (1.03–1.65) | (1.02–1.61) | ||
6.277×10−5 | 0.0284 | 0.0370 | |||
rs6984384 | 3.906×10−8 | 4.502×10−5 | 0.742 | 0.840 | 0.895 |
T | (0.65–0.86) | (0.74–0.96) | (0.79–1.02) | ||
4.886×10−5 | 0.008405 | 0.09511 | |||
rs701133 | 3.865×10−7 | 0.002081 | 1.547 | 1.206 | 1.160 |
T | (1.25–1.91) | (1.00–1.46) | (0.96–1.41) | ||
5.57×10−5 | 0.054 | 0.129 | |||
rs3019548 | 3.905×10−7 | 0.009792 | 1.541 | 1.483 | – |
G | (1.20–1.98) | (1.18–1.86) | |||
0.000643 | 0.000607 | ||||
rs6807700 | 1.061×10−7 | 0.0002289 | – | 1.46 | 1.49 |
C | (1.18–1.80) | (1.20–1.85) | |||
0.000400 | 0.000265 | ||||
rs17077265 | 2.80144×10−7 | 0.0131 | – | 1.409 | 1.062 |
T | (1.23–1.61) | (0.93–1.21) | |||
7.423×10−7 | 0.377 | ||||
rs522264 | 2.53×10−7 | 2.238×10−5 | – | 0.638 | 0.734 |
T | (0.51–0.79) | (0.59–0.91) | |||
5.567×10−5 | 0.00455 | ||||
rs6727857 | 4.819×10−7 | 0.000935 | – | 0.660 | 0.932 |
G | (0.56–0.78) | (0.79–1.10) | |||
1.173×10−6 | 0.411 |