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Table 5 Comparative analysis of brain-specific pathologies. Top 10 Enriched disorders were identified based on the GAD annotations for conserved and human-specific genes in the brain

From: Scope and limitations of yeast as a model organism for studying human tissue-specific pathways

Disorder

Conserved

Human-specific

 

genes

genes

Schizophrenia

0.008573

8.4905E-06

Autism

0.048288

0.00077448

Dementia

0.0014356

-

Schizophrenia; schizoaffective disorder; bipolar disorder

-

0.0021433

Myocardial infarct; cholesterol, HDL; triglycerides; atherosclerosis, coronary; macular degeneration; colorectal cancer

0.0051617

-

Epilepsy

0.071562

0.0064716

Seizures

-

0.020381

Bipolar disorder

0.048288

0.022016

Atention deficit disorder conduct disorder oppositional defiant disorder

0.032444

0.023865