Fig. 4

The integrated genetic and epigenetic cellular network for investigating the cellular mechanisms of normal and tumor tissues in liver cancer. The associations include the networks in tumor cells (dotted lines), normal cells (dashed lines), and both (solid lines). The bold lines indicate large genetic and epigenetic regulatory effects or genetic expression. Dysregulations of MIR141 and MIR335 contributes to dysfunction of DNA damage response and cell proliferation in human HCC, respectively