Enhanceosome transcription factors preferentially dimerize with high mobility group proteins

BMC Systems Biology

Table 4 p-values (minus log to the base 10 of reported p-values) for the Fisher’s exact test for similarity of GO terms enriched for human and mouse selected genes. Here we report only Q0 and Q6 selected genes

Dimer type	Dimer	p-value Q0 global	Best Q0 p-value	p-value Q6 global	Best Q6 p-value
HMG-A; ATF2	M00750; M00172	78.96	80.15 (HdL/416)	0.35	3.31 (HdA/Spl)
HMG-A; ATF2	M00750; M00188	72.44	40.97 (HLB/416)	1.51	1.73 (HLL/416)
HMG-A; ATF2	M00750; M00801	62.74	159.94 (HdA/CH)	0.37	14.16 (Th2/Thy)
IRF-A; IRF-B	M00772; M01881	0.61	2.01 (GM/Spl)	3.02	3.01 (CD/A20)
IRF-A; IRF-B	M00972; M00772	0.59	2.59 (GM/TRA)	13.22	10.42 (CD/TR)
IRF-A; IRF-B	M00972; M01881	7.27	9.22 (Mon/Bcl)	2.12	16.86 (ThW/TR)
IRF-A; IRF-B	M01881; M01881	7.94	10.16 (ThW/Bcl)	8.55	5.41 (CD/TR)

Column ‘p-value Q0 global’ refers to p-value of Fisher’s exact test for globaly selected genes (set union of all genes selected by the same dimer in different cell types). Column ‘best Q0 p-value’ shows minus log to the base 10 of the best reported p-value, names in brackets are cell types in human/mouse for which this p-value was achieved. Same explanation applies to Q6. Here are the abbreviations of the cell type names: (human) HdL = HMVEC-dLy-Neo, HdA = HMVEC-dAd, HLB = HMVEC-LBl, HLL = HMVEC-LLy, GM = GM12865, CD = CD2+_RO01778, Mon = Monocytes-CD14+_RO01746, ThW = Th2_Wb54553204; (mouse) 416 = 416B, Spl = Spleen, CH = CH12, Thy = Thymus, TRA = TReg-Activated, TR = TReg, Bcl = B-cell_(CD19+)

ISSN: 1752-0509