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Table 1 Fuzzy rules

From: Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity

RULE 1: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS high) and (CN IS amplified) THEN Gene_activity IS high_GoF;
RULE 2: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS high) and (CN IS neutral) THEN Gene_activity IS high_GoF;
RULE 3: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS high) and (CN IS deleted) THEN Gene_activity IS GoF;
RULE 4: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS medium) and (CN IS amplified) THEN Gene_activity IS high_GoF;
RULE 5: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS medium) and (CN IS neutral) THEN Gene_activity IS GoF;
RULE 6: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS medium) and (CN IS deleted) THEN Gene_activity IS low_GoF;
RULE 7: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS low) and (CN IS amplified) THEN Gene_activity IS high_GoF;
RULE 8: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS low) and (CN IS neutral) THEN Gene_activity IS GoF;
RULE 9: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS recurrent) and (Expression IS low) and (CN IS deleted) THEN Gene_activity IS no_effect;
RULE 10: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS high) and (CN IS amplified) THEN Gene_activity IS GoF;
RULE 11: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS high) and (CN IS neutral) THEN Gene_activity IS low_GoF;
RULE 12: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS high) and (CN IS deleted) THEN Gene_activity IS low_GoF;
RULE 13: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS medium) and (CN IS amplified) THEN Gene_activity IS low_GoF;
RULE 14: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS medium) and (CN IS neutral) THEN Gene_activity IS low_GoF;
RULE 15: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS medium) and (CN IS deleted) THEN Gene_activity IS no_effect;
RULE 16: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS low) and (CN IS amplified) THEN Gene_activity IS low_GoF;
RULE 17: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS low) and (CN IS neutral) THEN Gene_activity IS no_effect;
RULE 18: IF ((Mutation IS Missense_Mutation) or (Mutation IS In_Frame_Del) or (Mutation IS In_Frame_Ins)) and (Recurrence IS non_recurrent) and (Expression IS low) and (CN IS deleted) THEN Gene_activity IS no_effect;
RULE 19: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS high) and (CN IS amplified) THEN Gene_activity IS low_LoF;
RULE 20: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS high) and (CN IS neutral) THEN Gene_activity IS LoF;
RULE 21: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS high) and (CN IS deleted) THEN Gene_activity IS high_LoF;
RULE 22: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS medium) and (CN IS amplified) THEN Gene_activity IS LoF;
RULE 23: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS medium) and (CN IS neutral) THEN Gene_activity IS LoF;
RULE 24: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS medium) and (CN IS deleted) THEN Gene_activity IS high_LoF;
RULE 25: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS low) and (CN IS amplified) THEN Gene_activity IS high_LoF;
RULE 26: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS low) and (CN IS neutral) THEN Gene_activity IS high_LoF;
RULE 27: IF ((Mutation IS Frame_Shift_Ins) or (Mutation IS Frame_Shift_Del) or (Mutation IS Nonsense_Mutation) or (Mutation IS Nonstop_Mutation) or (Mutation IS Splice_Site)) and (Expression IS low) and (CN IS deleted) THEN Gene_activity IS high_LoF;
RULE 28: IF ((Mutation IS No_Mutation) and ((Expression IS low) or (CN IS deleted))) THEN Gene_activity IS LoF;
RULE 29: IF ((Mutation IS No_Mutation) and ((Expression IS high) or (CN IS amplified))) THEN Gene_activity IS low_GoF;
RULE 30: IF ((Mutation IS No_Mutation) and (Expression IS medium) and (CN IS neutral)) THEN Gene_activity IS no_effect;