Table 2 Gene targets and the predictors of sensitivity for the compounds
Compounds | Direct gene targets | Known sensitivity predictors | Sensitivity threshold | Resistance threshold |
|---|---|---|---|---|
PLX4720 | BRAF | BRAF mutation | A c t A r e a≥2.05 | A c t A r e a≤0.47 |
AZD6244 | MEK | BRAF mutation | A c t A r e a≥3.02 | A c t A r e a≤0.69 |
Erlotinib | EGFR | EGFR mutation | A c t A r e a≥1.74 | A c t A r e a≤0.42 |
Nutlin-3 | MDM2 | TP53 mutation | I C50≤4.26 | I C50≥6.94 |
| Â | Â | TP53 expression | Â | Â |
BYL719 | PIK3CA | PIK3CA mutation | E C50≤3.04 | E C50>3.04 |
|  |  |  | A m a x≤–30 | A m a x>–30 |