Skip to main content

Table 1 Correlations of Ub with toxicity endpoints

From: Low potency toxins reveal dense interaction networks in metabolism

Endpoint Number Ub5 Ub6
Trout 24 h 186 −0.230** −0.337***
Trout 96 h 181 −0.419*** −0.516***
Pteronarcys (24 h) 52 −0.433** −0.385**
Pteronarcys (96 h) 52 −0.456*** −0.369**
Bluegill (24 h) 157 −0.149 −0.215**
Bluegill (96 h) 172 −0.216** −0.276***
Gammarus (24 h) 113 −0.437*** −0.208*
Gammarus (96 h) 132 −0.407*** −0.205*
Fathead minnow 578 −0.311*** −0.308***
Rat oral 814 −0.441*** −0.372***
Mouse oral 398 −0.199*** −0.191***
Rat IP 170 −0.214** −0.147
Mouse IP 290 −0.180** −0.161**
AMES (mutagenicity) 163 −0.316*** −0.518***
CPDBAS rat 519 −0.198*** −0.191***
CPDBAS mouse 402 −0.145** −0.198***
CPDBAS hamster 44 −0.430** −0.351*
Drosophila 139 −0.397*** −0.337***
Lemna - non-Herbicides 149 −0.428*** −0.502***
Lemna - Herbicides 174 −0.392*** −0.428***
Tetrahymena 334 −0.408*** −0.448***
Chlorella 91 −0.578*** −0.738***
Scenedesmus 63 −0.237 −0.467***
Yeast 253 0.095 −0.014
NCI 768 −0.113** −0.137***
  1. Rank Correlation coefficient between toxicity endpoints and UnBiological (Ub) measures. Two Ub measures are shown – Ub 5 and Ub 6 , calculated from an overlap of 5 and 6 atoms between target molecule and the pool of metabolites. See Appendix 2 for more detailed descriptions of calculation of Ub. Column 1: toxicity endpoint. Column 2: number of data points. Column 3 and 4: correlation of Ub 5 and Ub 6 respectively with appropriate toxicity endpoint. Significance of the correlation of flagged by asterisks.* = p < 0.05.** = p < 0.01*** = p < 0.000714. Note that*** is a value selected to be 0.05/(35*2), to correct for multiple testing of 35 toxicity endpoints and 2 correlates. If Ub 5 and Ub 6 were randomly distributed with respect to toxicity, then we would expect to have to do this study 20 times to come up with one correlation of p < 0.000714