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Fig. 3 | BMC Systems Biology

Fig. 3

From: Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation

Fig. 3

Model results suggest that IGF2R can suppress phosphorylation of IGF1R for specific quantitative combinations. a Model analysis demonstrated that IGF2R would need to be 100 times more abundant than IGF1R in order to inhibit pIGF1R by 11.2 % in OVCAR5. b Increasing IGF2 treatment doses increased the magnitude of IGF2R:IGF1R ratio required for 50 % inhibition of pIGF1R

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BMC Systems Biology

ISSN: 1752-0509

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