Fig. 6

Sensitivity analysis demonstrated that pIGF1R was insensitive to changes in the IGF2R network. a Sensitivity of the integrated level of pIGF1R when individual rate parameters were changed. A positive value indicates an increase in the level of pIGF1R. b Sensitivity of the integrated level of pIGF1R when rate parameters are changed in combination with a 10-fold increase in the level of IGF2R. Parameters were altered such that both perturbations resulted in a decrease in the level of pIGF1R